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The U.S. Food and Drug Administration (FDA) banned the sale of dietary supplements containing ephedrine alkaloids (stimulant compounds found in Ephedra sinica and some other plants) in the United States in 2004. Prior to the ban, ephedra was an ingredient in some dietary supplements promoted for weight loss, increased energy, and enhanced athletic performance.

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Namely exercise, weight-loss, and sexual-enhancement supplements. The products analyzed in the JAMA study fell into these three categories. Several of the weight-loss supplements actually Higenamine is showing up in products promoted as a pre-workout supplement for improving athletic performance. However, higenamine is prohibited in sports. It is on the World Anti-Doping Agency Dietary supplements taken by millions of Americans can cause serious health problems and even death. similar to ephedrine, which the FDA banned in 2004. larreastat - is used for colds